Can mathematical analysis help uncover the design principles behind circadian rhythms?
David Rand, Systems Biology Centre, University of Warwick (October 27, 2010)
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I will survey what some recent mathematical results suggest about the design principles behind circadian clocks. In particular, I will discuss flexibility, robustness, buffering mechanisms against environmental heterogeneity, temperature compensation in physiological entrained conditions and tracking of multiple phases. If time permits I will also discuss new methods for fitting reporter time series data to models.