Can mathematical analysis help uncover the design principles behind circadian rhythms?

David Rand (October 27, 2010)

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Abstract

I will survey what some recent mathematical results suggest about the design principles behind circadian clocks. In particular, I will discuss flexibility, robustness, buffering mechanisms against environmental heterogeneity, temperature compensation in physiological entrained conditions and tracking of multiple phases. If time permits I will also discuss new methods for fitting reporter time series data to models.